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Brand Name :
N/A
Synonyms :
Menadiol, dihydro vitamin K3
Class :
Vitamin K analogues
Brand Name :
N/A
Synonyms :
Menadiol, dihydro vitamin K3
Class :
Vitamin K analogues
ADULT DOSING
Dosage Forms & Strengths
Tablets
10mg
Hemorrhage due to low levels of prothrombin
10mg- 40mg every day
10mg- 40mg every day
PEDIATRIC DOSING
Dosage Forms & Strengths
Tablets
10mg
Hemorrhage due to low levels of prothrombin
5mg- 20mg every day
For children aged 1 to 12 years
5mg- 10mg per day
depending on the response of the patient, the dose may be adjusted accordingly
For children aged 12 to 18 years
10mg – 20mg per day
depending on the response of the patient, the dose may be adjusted accordingly
GERIATRIC DOSING
Refer to adult dosing
5mg- 20mg every day
For children aged 1 to 12 years
5mg- 10mg per day
depending on the response of the patient, the dose may be adjusted accordingly
For children aged 12 to 18 years
10mg – 20mg per day
depending on the response of the patient, the dose may be adjusted accordingly
Actions and spectrum:
Menadiol acts as an electron donor in submitochondrial particles for oxidative phosphorylation (reversed).
This is necessary for the formation of prothrombin, factor IX and X.
Frequency not defined
Hemolysis
Black Box Warning
No special black box warning is available
Contraindication/Caution:
Contraindication:
Infants
Neonates
Peri-natal period
Galactosemia
3rd trimester of pregnancy
Precautions:
Glucose-galactose malabsorption syndrome
G6PD deficiency
Deficiency of Vitamin E
Lactose intolerance
Chances of development of hyperbilirubinemia in premature infants and neonates
Possibility of kernicterus in premature infants and neonates
Possibility of hemolytic anemia in premature infants and neonates
Pregnancy consideration:
Menadiol is contraindicated in late phase or 3rd trimester of pregnancy
Lactation:
It is considered safe to use menadiol in lactation.
Pregnancy categories:
Category A: Studies that were well-controlled and met expectations revealed no risk to the fetus in either the first or second trimester.
Category B: There was a lack of studies on pregnant women and no evidence of risk to the fetus in animal experiments.
Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.
Category D: adequate data with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.
Category X: Drugs listed in this category outweigh the risks over benefits. Hence, these categories of drugs need to be avoided by pregnant women.
Category N: There is no data available for the drug under this category
Pharmacology:
Menadiol, an organic compound, is obtained naturally by reducing menadione.
Pharmacodynamics:
Limited data available
Pharmacokinetics:
Limited data available
Administration:
Menadiol tablets should be administered orally as suggested by the physician.
Patient information leaflet
Generic Name: menadiol
Why do we use menadiol?
Menadiol is an organic compound obtained naturally from menadione used to treat hemorrhage caused by low levels of prothrombin. It is also indicated for treating certain kinds of jaundice and preventing excessive bleeding.
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